EVIDENCE-BASED SUPPLEMENT SCORING
6.2/10
AVERAGE

Confidence: 80%

Pure Encapsulations O.N.E. Multivitamin - Once Daily Multivitamin with Antioxidant Complex Metafolin, CoQ10, and Lutein to Support Vision, Cognitive Function, and Cellular Health* - 120 Capsules

Pure Encapsulations O.N.E. Multivitamin - Once Daily Multivitamin with Antioxidant Complex Metafolin, CoQ10, and Lutein to Support Vision, Cognitive Function, and Cellular Health* - 120 Capsules

B01BGZVXC6

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Decision summary

CONSIDERAVERAGE

A middling option. It may be usable, but weaker formulation coherence makes better alternatives worth comparing.

Best for

Buyers comparing price and availability and okay with a middle-of-the-pack option.

Consider another option if

You care a lot about ingredient quality and effectiveness.

Score breakdown

Tap a module to see what it measures. A 0 can reflect missing disclosure, not just a negative result.

Dosage quality

5.5/10

Acceptable dosing, but not standout

Checks whether labeled ingredient amounts fall within clinically studied ranges (not just regulatory minimums). Low/0 can reflect under-dosing or missing amounts (e.g., proprietary blends).

Multi-ingredient formulation analysis

Dose 5.5/10 · Bioavailability 2.8/10 · Coherence 0/10

Ingredient form quality suggests suboptimal ingredient forms.

This is a multi-ingredient product. The score reflects formulation quality, not efficacy for a specific health goal.

Score summary

Vitamin-a: dose within clinically studied range (evidence A). The main limitation is that lutein: below clinically studied range.

Strengths

Vitamin-a: dose within clinically studied range (evidence A)
Vitamin-b12: dose within clinically studied range (evidence B)
Vitamin-b5: dose within clinically studied range (evidence B)

Weaknesses

Lutein: below clinically studied range
Formula coherence is weak: diluted, decorative or overly complex
Vitamin-d: below clinically studied range

Final verdict

A middling option. It may be usable, but weaker formulation coherence makes better alternatives worth comparing.

Ingredient Analysis & Evidence

A closer look at the main ingredients, how they influence the score, and the supporting evidence when available. Tap any ingredient to expand.

⚠ Strong evidence exists, but dose is below effective threshold

One of the weaker points: Dose is likely below clinically useful levels.

Scientific evidence

Meta-analysis

Ma et al. meta-analysis lutein/zeaxanthin and age-related macular degeneration

British Journal of Nutrition • 2012

PMID: 26447482.0

RCT

Ma et al. RCT lutein supplementation and macular pigment density

Investigative Ophthalmology & Visual Science • 2009

PMID: 16723441.0

✔ Clinically effective dose with strong supporting evidence

Adequate, but not a key strength: Dose is directionally useful, but not a standout strength. The declared form is acceptable, but not among the best-absorbed options.

Scientific evidence

Meta-analysis

Singh & Das Cochrane review zinc for common cold

Cochrane Database of Systematic Reviews • 2011

PMID: 22553186.0

RCT

Prasad et al. RCT zinc supplementation and testosterone in elderly men

Nutrition • 1996

PMID: 8875519.0

✔ Clinically effective dose with moderate supporting evidence

Strong contributor: Dose is strong and within effective ranges. The declared form is acceptable, but not among the best-absorbed options.

Scientific evidence

Meta-analysis

Clarke et al. meta-analysis B vitamins and cognitive decline

American Journal of Clinical Nutrition • 2007

PMID: 22243457.0

RCT

Shipton & Thachil review of vitamin B12 deficiency and fatigue

Postgraduate Medical Journal • 2015

PMID: 20648714.0

ℹ Dose is within established clinical ranges, but lacks direct studies

This is a limiting factor: Dose is below the ranges usually used for stronger effects. The declared form is acceptable, but not among the best-absorbed options.

Clinical dosing guidance

Based on established dosing ranges used in clinical practice.

Min effective: 1.8 mgOptimal: 2.5 mgUpper: 11 mgGrade: B

ℹ Dose is within established clinical ranges, but lacks direct studies

Adequate, but not a key strength: Dose is directionally useful, but not a standout strength.

Clinical dosing guidance

Based on established dosing ranges used in clinical practice.

Min effective: 1 mgOptimal: 5 mgUpper: 100 mgGrade: B

ℹ Clinically effective dose, but evidence is limited

Dose is well positioned: Dose is strong and within effective ranges.

Scientific evidence

narrative_review

Hodges et al. review on pantothenic acid physiology and human deficiency implications

Advances in Nutrition • 2020

Pure Encapsulations O.N.E. Multivitamin - Once Daily Multivitamin with Antioxidant Complex Metafolin, CoQ10, and Lutein to Support Vision, Cognitive Function, and Cellular Health* - 120 Capsules

Pure Encapsulations O.N.E. Multivitamin - Once Daily Multivitamin with Antioxidant Complex Metafolin, CoQ10, and Lutein to Support Vision, Cognitive Function, and Cellular Health* - 120 Capsules

Warnings & notes

Important label or formulation details that may affect how this product should be interpreted.

!

Lutein dose looks below clinically effective levels

Declared amount falls below ranges used in human trials.

Warning

Formula design looks less coherent than stronger alternatives

The formulation appears less focused than better-built options.

Note
!

Vitamin D dose looks below clinically effective levels

Declared amount falls below ranges used in human trials.

Warning

Methodology

Read our methodology overview to understand how SuppScoreLab combines multiple scientific dimensions into one practical score.

View methodology →

This evaluation is based on the product label and declared Supplement Facts available at review time. It does not verify laboratory-tested composition, purity, or batch-level quality. This content is educational and not medical advice. Consult a qualified healthcare professional for personal health decisions. Affiliate disclosure: SuppScoreLab may earn a commission from qualifying Amazon links.

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