EVIDENCE-BASED SUPPLEMENT SCORING
5.1/10
WEAK

Confidence: 75%

Berberine HCl 500 mg with Ceylon Cinnamon, Turmeric, Milk Thistle, Bitter Gourd & Alpha Lipoic Acid - Non-GMO, Gluten Free, Vegan Capsules - 60 Count

Berberine HCl 500 mg with Ceylon Cinnamon, Turmeric, Milk Thistle, Bitter Gourd & Alpha Lipoic Acid - Non-GMO, Gluten Free, Vegan Capsules - 60 Count

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Decision summary

SKIPWEAK

Not a strong option overall. The product is materially held back by weaker formulation coherence.

Best for

Only budget-focused buyers with flexible standards.

Consider another option if

You care a lot about label clarity and want fewer unknowns.

Score breakdown

Tap a module to see what it measures. A 0 can reflect missing disclosure, not just a negative result.

Dosage quality

3.0/10

Dosing looks weaker than ideal

Checks whether labeled ingredient amounts fall within clinically studied ranges (not just regulatory minimums). Low/0 can reflect under-dosing or missing amounts (e.g., proprietary blends).

Multi-ingredient formulation analysis

Dose 3/10 · Bioavailability 1.1/10 · Coherence 0/10

Dose quality suggests a diluted formulation.

Ingredient form quality suggests suboptimal ingredient forms.

Some ingredient forms are not declared on the label.

This is a multi-ingredient product. The score reflects formulation quality, not efficacy for a specific health goal.

Score summary

The formula stays relatively clean on excipients. The main limitation is that turmeric: below clinically studied range.

Strengths

The formula stays relatively clean on excipients
The safety profile looks solid
The supporting evidence profile is relatively strong

Weaknesses

Turmeric: below clinically studied range
Turmeric: chemical form not specified on label
Formula coherence is weak: diluted, decorative or overly complex

Final verdict

Not a strong option overall. The product is materially held back by weaker formulation coherence.

Ingredient Analysis & Evidence

A closer look at the main ingredients, how they influence the score, and the supporting evidence when available. Tap any ingredient to expand.

ℹ Evidence is strong, but dose is below the optimal range

One of the weaker points: Dose is below the ranges usually used for stronger effects.

Scientific evidence

Meta-analysis

Lan et al. meta-analysis berberine and lipid profile

Journal of Ethnopharmacology • 2015

PMID: 26448206.0

Meta-analysis

Dong et al. meta-analysis berberine and glycemic control in type 2 diabetes

Metabolism • 2012

PMID: 22162995.0

⚠ Strong evidence exists, but dose is below effective threshold

A clear drag on the formula: Dose is likely below clinically useful levels. The label does not specify the form, so absorption quality cannot be verified.

Scientific evidence

Meta-analysis

Daily et al. meta-analysis curcuminoids and joint pain

Journal of Medicinal Food • 2016

PMID: 27533649.0

ℹ Dose is within established clinical ranges, but lacks direct studies

One of the weaker points: Dose is below the ranges usually used for stronger effects. The declared form is acceptable, but not among the best-absorbed options.

Clinical dosing guidance

Based on established dosing ranges used in clinical practice.

Min effective: 5 mgOptimal: 10 mgUpper: 20 mgGrade: B

✔ Dose aligned with moderate supporting evidence

Solid but not a standout: Clinical dosing guidance is limited for this ingredient. The declared form is acceptable, but not among the best-absorbed options.

Scientific evidence

Meta-analysis

Rambaldi et al. Cochrane review silymarin for alcoholic or hepatitis liver disease

Cochrane Database of Systematic Reviews • 2007

PMID: 22517298.0

⚠ Limited evidence exists, and dose is below effective threshold

This is a limiting factor: Dose is likely below clinically useful levels.

Scientific evidence

Meta-analysis

Fuangchan et al. meta-analysis bitter melon and type 2 diabetes

Journal of Ethnopharmacology • 2011

PMID: 23777923.0

⚠ Moderate evidence exists, but dose is below effective threshold

A clear drag on the formula: Dose is likely below clinically useful levels. The label does not specify the form, so absorption quality cannot be verified.

Scientific evidence

Meta-analysis

Akbari et al. meta-analysis ALA and oxidative stress markers

Clinical Nutrition • 2018

PMID: 26544715.0

Meta-analysis

Solmonides et al. meta-analysis ALA and glycemic control

Obesity Reviews • 2011

PMID: 22830575.0

Berberine HCl 500 mg with Ceylon Cinnamon, Turmeric, Milk Thistle, Bitter Gourd & Alpha Lipoic Acid - Non-GMO, Gluten Free, Vegan Capsules - 60 Count

Berberine HCl 500 mg with Ceylon Cinnamon, Turmeric, Milk Thistle, Bitter Gourd & Alpha Lipoic Acid - Non-GMO, Gluten Free, Vegan Capsules - 60 Count

Warnings & notes

Important label or formulation details that may affect how this product should be interpreted.

!

Turmeric dose looks below clinically effective levels

Declared amount falls below ranges used in human trials.

Warning
i

Turmeric form is not clearly declared

Exact ingredient form is not disclosed on the label.

Info

Formula design looks less coherent than stronger alternatives

The formulation appears less focused than better-built options.

Note

Methodology

Read our methodology overview to understand how SuppScoreLab combines multiple scientific dimensions into one practical score.

View methodology →

This evaluation is based on the product label and declared Supplement Facts available at review time. It does not verify laboratory-tested composition, purity, or batch-level quality. This content is educational and not medical advice. Consult a qualified healthcare professional for personal health decisions. Affiliate disclosure: SuppScoreLab may earn a commission from qualifying Amazon links.

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